Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.57 |
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | GPR183 | P32249 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.54 |
| ▸ | LMNA | P02545 | 9/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.48 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190933 | 1.00 | MAPT (0.57) | MAPTSMN1; SMN2L3MBTL1HTTKMT2A | |
| SCHEMBL14190904 | 0.94 | MAPT (0.62) | MAPTSMN1; SMN2L3MBTL1HTTKMT2A | |
| SCHEMBL4379027 | 0.94 | MAPT (0.62) | MAPTSMN1; SMN2L3MBTL1HTTKMT2A | |
| SCHEMBL14190955 | 0.84 | MAPT (0.59) | MAPTSMN1; SMN2L3MBTL1HTTKMT2A | |
| SCHEMBL4375431 | 0.84 | MAPT (0.59) | MAPTSMN1; SMN2L3MBTL1HTTKMT2A | |
| SCHEMBL14190934 | 0.82 | MAPT (0.61) | MAPTSMN1; SMN2L3MBTL1HTTKMT2A | |
| SCHEMBL4378302 | 0.82 | MAPT (0.61) | MAPTSMN1; SMN2L3MBTL1HTTKMT2A | |
| SCHEMBL13636002 | 0.79 | MAPT (0.60) | MAPTSMN1; SMN2L3MBTL1HTTKMT2A | |
| SCHEMBL4382804 | 0.79 | MAPT (0.60) | MAPTSMN1; SMN2L3MBTL1HTTKMT2A | |
| SCHEMBL4379308 | 0.79 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2L3MBTL1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
| US-7208497-B2 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2007-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | MAPT 1441/4885SMN1; SMN2 2684/4885L3MBTL1 4039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.