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SCHEMBL4376263

SCHEMBL4376263

CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)sc3C(=O)N3CCNC(=O)C3)cc2)ccn1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 13/20 0.50
▸ RAF1 P04049 7/20 0.50
▸ KDR P35968 3/20 0.50
▸ EPHX2 P34913 3/20 0.50
▸ BRAF P15056 2/20 0.48
▸ SRC P12931 3/20 0.47
▸ ABL1 P00519 3/20 0.47
▸ PLK4 O00444 2/20 0.47
▸ AURKA O14965 2/20 0.47
▸ MAPK13 O15264 2/20 0.47
▸ MAP4K4 O95819 2/20 0.47
▸ LCK P06239 2/20 0.47
▸ FYN P06241 2/20 0.47
▸ LYN P07948 2/20 0.47
▸ RET P07949 2/20 0.47
▸ RPS6KB1 P23443 2/20 0.47
▸ EPHA2 P29317 2/20 0.47
▸ AXL P30530 2/20 0.47
▸ FRK P42685 2/20 0.47
▸ MAPK9 P45984 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4370809 0.94 MAPK14 (0.51) MAPK14RAF1KDREPHX2BRAF
SCHEMBL4372572 0.89 MAPK14 (0.56) MAPK14RAF1MAPK13RPS6KB1
SCHEMBL4375658 0.88 MAPK14 (0.66) MAPK14RAF1KDREPHX2BRAF
SCHEMBL4371790 0.86 MAPK14 (0.53) MAPK14RAF1KDREPHX2BRAF
SCHEMBL4367329 0.86 MAPK14 (0.63) MAPK14RAF1KDREPHX2BRAF
SCHEMBL4376141 0.83 RAF1 (0.61) MAPK14RAF1KDREPHX2BRAF
SCHEMBL4379198 0.82 MAPK14 (0.67) MAPK14RAF1KDREPHX2BRAF
SCHEMBL4370767 0.82 MAPK14 (0.57) MAPK14RAF1MAPK13RPS6KB1MAPK12
SCHEMBL4364689 0.76 MAPK14 (0.75) MAPK14MAPK13RPS6KB1MAPK12MAPK11
SCHEMBL4367493 0.75 MAPK14 (0.66) MAPK14RAF1KDREPHX2BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1824843-A2 INHIBITORS OF PROTEIN KINASES Locus Pharmaceuticals, Inc. (US) 2007-08-29 — — EP claimed
WO-2006062984-A2 INHIBITORS OF PROTEIN KINASES LOCUS PHARMACEUTICALS, INC. (US) 2006-06-15 — — WO claimed
US-7612200-B2 Inhibitors of protein kinases LOCUS PHARMACEUTICALS, INC. (US) 2009-11-03 — — US disclosed
US-7612200-B2 Inhibitors of protein kinases LOCUS PHARMACEUTICALS, INC. (US) 2009-11-03 — — US disclosed
US-7612200-B2 Inhibitors of protein kinases LOCUS PHARMACEUTICALS, INC. (US) 2009-11-03 — — US disclosed
US-20090192307-A1 INHIBITORS OF PROTEIN KINASES LOCUS PHARMACEUTICALS, INC. 2009-07-30 — — US disclosed
US-20090192307-A1 INHIBITORS OF PROTEIN KINASES LOCUS PHARMACEUTICALS, INC. 2009-07-30 — — US disclosed
US-20090192307-A1 INHIBITORS OF PROTEIN KINASES LOCUS PHARMACEUTICALS, INC. 2009-07-30 — — US disclosed
EP-1824843-A2 INHIBITORS OF PROTEIN KINASES Locus Pharmaceuticals, Inc. (US) 2007-08-29 — — EP disclosed
WO-2006062984-A2 INHIBITORS OF PROTEIN KINASES LOCUS PHARMACEUTICALS, INC. (US) 2006-06-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090192307-A1 INHIBITORS OF PROTEIN KINASES MAP3K20, MAP3K1, MAP3K19 MAPK14 300/4885RAF1 37/4885KDR 960/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.