Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 19/20 | 0.54 |
| ▸ | GRIA4 | P48058 | 19/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375263 | 0.83 | GRIA2 (0.57) | GRIA2GRIA4 | |
| SCHEMBL4373295 | 0.82 | GRIA2 (0.59) | GRIA2GRIA4 | |
| SCHEMBL8289329 | 0.82 | GRIA4 (0.64) | GRIA2GRIA4 | |
| SCHEMBL8289784 | 0.82 | GRIA2 (0.60) | GRIA2GRIA4KDM4EMEN1ALDH1A1 | |
| SCHEMBL4372732 | 0.81 | GRIA4 (0.76) | GRIA2GRIA4 | |
| SCHEMBL13604491 | 0.81 | GRIA2 (0.51) | GRIA2GRIA4MEN1ALDH1A1KMT2A | |
| SCHEMBL8288386 | 0.81 | GRIA2 (0.65) | GRIA2GRIA4 | |
| SCHEMBL8289349 | 0.81 | GRIA2 (0.77) | GRIA2GRIA4KDM4EMEN1ALDH1A1 | |
| SCHEMBL8289332 | 0.80 | GRIA2 (0.65) | GRIA2GRIA4KDM4E | |
| SCHEMBL8289350 | 0.80 | GRIA2 (0.74) | GRIA2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |