Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 12/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379894 | 0.93 | MAPK13 (0.53) | MAPK13MAPK14RAF1MAPK1ABL1 | |
| SCHEMBL380017 | 0.92 | MAPK13 (0.53) | MAPK13MAPK14RAF1MAPK1LCK | |
| SCHEMBL379934 | 0.91 | MAPK14 (0.49) | MAPK13MAPK14RAF1MAPK1LCK | |
| SCHEMBL379819 | 0.89 | MAPK13 (0.67) | MAPK13MAPK14RAF1MAPK1LCK | |
| SCHEMBL379705 | 0.86 | MAPK14 (0.55) | MAPK13MAPK14RAF1MAPK1 | |
| SCHEMBL379772 | 0.86 | MAPK14 (0.56) | MAPK13MAPK14RAF1MAPK1LCK | |
| SCHEMBL379509 | 0.84 | MAPK13 (0.51) | MAPK13MAPK14RAF1ABL1LCK | |
| SCHEMBL379448 | 0.81 | MAPK13 (0.79) | MAPK13MAPK14RAF1 | |
| SCHEMBL380013 | 0.81 | MAPK13 (0.46) | MAPK13MAPK14RAF1MAPK1LCK | |
| SCHEMBL380491 | 0.81 | MAPK13 (0.46) | MAPK13MAPK14RAF1MAPK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086973-B1 | IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF | AMGEN INC (US) | 2012-01-25 | — | — | EP | disclosed |