Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 13/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADA | P00813 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2847280 | 0.85 | ADORA2A (0.50) | ADORA2AHDAC1ADORA1ADORA3ADORA2B | |
| SCHEMBL14019391 | 0.85 | ADORA2A (0.50) | ADORA2AHDAC1ADORA1 | |
| SCHEMBL2843175 | 0.84 | ADORA2A (0.49) | ADORA2AHDAC1ADORA1ADORA3ADORA2B | |
| SCHEMBL2850837 | 0.84 | ADORA2A (0.49) | ADORA2AHDAC1ADORA1ADORA3ADORA2B | |
| SCHEMBL2843866 | 0.84 | ADORA2A (0.46) | ADORA2AHDAC1ADORA1ADORA3ADORA2B | |
| SCHEMBL2848249 | 0.81 | ADORA2A (0.49) | ADORA2AHDAC1ADORA1ADORA3ADORA2B | |
| SCHEMBL8149252 | 0.80 | ADORA2A (0.49) | ADORA2AHDAC1ADORA1 | |
| SCHEMBL2846190 | 0.79 | ADORA2A (0.56) | ADORA2AHDAC1ADORA1ADORA3ADORA2B | |
| SCHEMBL2848487 | 0.78 | ADORA2A (0.50) | ADORA2AHDAC1ADA | |
| SCHEMBL2853601 | 0.77 | ADORA2A (0.61) | ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129220-A2 | ADENOSINE A2A RECEPTOR ANTAGONISTS | King Pharmaceuticals Research and Development Inc. (US) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008121748-A2 | ADENOSINE A2A RECEPTOR ANTAGONISTS | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT,INC. (US) | 2008-10-09 | — | — | WO | disclosed |