Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.72 |
| ▸ | CNR1 | P21554 | 1/20 | 0.72 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.72 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.72 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.56 |
| ▸ | GABRP | O00591 | 3/20 | 0.55 |
| ▸ | GABRD | O14764 | 3/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.55 |
| ▸ | GABRE | P78334 | 3/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.55 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.55 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.55 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371914 | 0.88 | PDE4D (0.74) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| Nordazepam SCHEMBL29354494 | 0.84 | PDE4D (1.00) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| Nordazepam SCHEMBL8090999 | 0.84 | PDE4D (1.00) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| Nordazepam SCHEMBL31000330 | 0.84 | PDE4D (1.00) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| Nordazepam SCHEMBL78453 | 0.84 | PDE4D (1.00) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| SCHEMBL4373660 | 0.81 | PDE4D (0.74) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| SCHEMBL9654207 | 0.80 | PDE4D (0.61) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| SCHEMBL4371135 | 0.79 | CNR1 (0.64) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| SCHEMBL10770717 | 0.79 | PDE4D (0.63) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| SCHEMBL21129434 | 0.77 | PDE4D (0.68) | PDE4DCNR1NTSR1OPRK1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339709-B1 | FARNESYL TRANSFERASE INHIBITING BENZOHETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-24 | — | — | EP | disclosed |
| US-7153958-B2 | Farnesyl transferase inhibiting benzoheterocyclic derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-26 | — | — | US | disclosed |
| US-20040034218-A1 | Farnesyl transferase inhibiting benzoheterocyclic derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-02-19 | — | — | US | disclosed |
| EP-1339709-A1 | FARNESYL TRANSFERASE INHIBITING BENZOHETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002042296-A1 | FARNESYL TRANSFERASE INHIBITING BENZOHETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034218-A1 | Farnesyl transferase inhibiting benzoheterocyclic derivatives | FNTA, FNTB, RCE1 | PDE4D 4099/4885CNR1 2003/4885NTSR1 2621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.