Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | ADK | P55263 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11089506 | 0.83 | MTOR (0.45) | TAAR1CYP19A1NISCHMTORADK | |
| Trityl Imidazole SCHEMBL1572623 | 0.83 | MTOR (0.45) | TAAR1CYP19A1NISCHMTORADK | |
| SCHEMBL7405799 | 0.81 | CYP19A1 (0.36) | TAAR1CYP19A1NISCHMTORADK | |
| SCHEMBL1572413 | 0.81 | CYP19A1 (0.43) | TAAR1CYP19A1NISCHMTORADK | |
| SCHEMBL5738213 | 0.81 | NISCH (0.43) | TAAR1CYP19A1NISCHMTORADK | |
| SCHEMBL10894207 | 0.80 | TAAR1 (0.35) | TAAR1CYP19A1 | |
| SCHEMBL11691051 | 0.79 | CYP19A1 (0.35) | TAAR1CYP19A1NISCHMTORADK | |
| SCHEMBL11867753 | 0.78 | CYP19A1 (0.43) | TAAR1CYP19A1NISCHMTORADK | |
| SCHEMBL9826276 | 0.77 | MLNR (0.47) | TAAR1CYP19A1NISCHMTORADK | |
| SCHEMBL9632116 | 0.75 | TSHR (0.43) | TAAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101762-A1 | NOVEL 2 -IMIDAZOLES AS LIGANDS FOR TRACE AMINE ASSOCIATED RECEPTORS (TAAR) | F. Hoffmann-Roche AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008071574-A1 | NOVEL 2 -IMIDAZOLES AS LIGANDS FOR TRACE AMINE ASSOCIATED RECEPTORS (TAAR) | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-19 | — | — | WO | disclosed |