Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 17/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL603607 | 0.86 | HRH4 (0.66) | HRH4HRH3KCNH2ADRB1TACR2 | |
| SCHEMBL606471 | 0.76 | HRH4 (0.59) | HRH4HRH3KCNH2ADRB1TACR2 | |
| SCHEMBL606676 | 0.70 | HRH4 (1.00) | HRH4HRH3KCNH2ADRB1TACR2 | |
| SCHEMBL603530 | 0.67 | HRH4 (0.93) | HRH4HRH3KCNH2ADRB1TACR2 | |
| SCHEMBL606371 | 0.66 | HRH4 (0.57) | HRH4HRH3KCNH2ADRB1TACR2 | |
| SCHEMBL606370 | 0.66 | HRH4 (0.57) | HRH4HRH3KCNH2ADRB1TACR2 | |
| SCHEMBL604362 | 0.66 | HRH4 (0.57) | HRH4HRH3KCNH2ADRB1TACR2 | |
| SCHEMBL604363 | 0.66 | HRH4 (0.57) | HRH4HRH3KCNH2ADRB1TACR2 | |
| SCHEMBL604361 | 0.66 | HRH4 (0.57) | HRH4HRH3KCNH2ADRB1TACR2 | |
| SCHEMBL604979 | 0.65 | HRH4 (0.70) | HRH4HRH3KCNH2ADRB1TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123967-A1 | 5,6,7,8-TETRAHYDROQUINAZOLIN-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS HISTAMINE H4 RECEPTOR MODULATORS FOR THE TREATMENT OF ASTHMA | ABBOTT LABORATORIES (US) | 2009-10-08 | — | — | WO | disclosed |