Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.69 |
| ▸ | HTR3A | P46098 | 4/20 | 0.57 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL715585 | 0.82 | PDE5A (1.00) | PDE5AHTR3AHRH4TBXAS1PDE3B | |
| SCHEMBL7431759 | 0.82 | PDE5A (0.69) | PDE5ATBXAS1PDE3BPDE3APTGS1 | |
| SCHEMBL7373964 | 0.82 | PDE5A (0.69) | PDE5AHTR3AHRH4TBXAS1PDE3B | |
| Hydrochloric Acid SCHEMBL7280241 | 0.81 | PDE5A (1.00) | PDE5AHTR3AHRH4TBXAS1PDE3B | |
| Hydrochloric Acid SCHEMBL7443205 | 0.81 | PDE5A (0.69) | PDE5AHTR3AHRH4TBXAS1PDE3B | |
| SCHEMBL7278005 | 0.77 | PDE5A (0.71) | PDE5AHTR3AHRH4TBXAS1PDE3B | |
| SCHEMBL7280014 | 0.77 | PDE5A (0.65) | PDE5AHTR3AHRH4TBXAS1PDE3B | |
| SCHEMBL7280235 | 0.76 | PDE5A (0.64) | PDE5AHTR3AHRH4TBXAS1PDE3B | |
| Hydrochloric Acid SCHEMBL7279626 | 0.76 | PDE5A (0.66) | PDE5AHTR3AHRH4TBXAS1PDE3B | |
| Hydrochloric Acid SCHEMBL7287960 | 0.76 | PDE5A (0.64) | PDE5AHTR3AHRH4TBXAS1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117542-A1 | COMBINATIONS OF BETA- 2 -ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE | AstraZeneca AB (SE) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008096111-A1 | COMBINATIONS OF BETA- 2 -ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008096121-A1 | COMBINATIONS OF BETA-2-ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | WO | disclosed |