SCHEMBL4383280

SCHEMBL4383280

Cc1cc(OCc2ccc(F)cc2F)cc(=O)n1-c1c(Cl)ccc(Br)c1Cl

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 19/20 0.56
MAPKAPK2 P49137 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4374553 0.83 MAPK14 (0.58) MAPK14
SCHEMBL4376955 0.83 MAPK14 (0.56) MAPK14
SCHEMBL4384410 0.82 MAPK14 (0.48) MAPK14
SCHEMBL4381266 0.81 MAPK14 (0.65) MAPK14
SCHEMBL4381727 0.80 MAPK14 (0.65) MAPK14
SCHEMBL4382150 0.78 MAPK14 (0.48) MAPK14MAPKAPK2
SCHEMBL4385052 0.77 MAPK14 (0.49) MAPK14
SCHEMBL4379278 0.77 MAPK14 (0.67) MAPK14
SCHEMBL9110310 0.77 MAPKAPK2 (0.51) MAPK14MAPKAPK2
SCHEMBL17809524 0.77 MAPK14 (0.66) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1490064-B1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE PHARMACIA CORP (US) 2009-11-18 EP claimed