Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.68 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1233583 | 0.81 | MAPK14 (1.00) | MAPK14RAF1NTRK1HTR1B | |
| SCHEMBL1233180 | 0.66 | MAPK14 (0.66) | MAPK14RAF1NTRK1HTR1B | |
| SCHEMBL1233406 | 0.66 | MAPK14 (0.69) | MAPK14RAF1NTRK1HTR1B | |
| SCHEMBL2076446 | 0.66 | MAPK14 (0.74) | MAPK14RAF1NTRK1HTR1B | |
| SCHEMBL12782861 | 0.66 | MAPK14 (1.00) | MAPK14RAF1NTRK1HTR1B | |
| SCHEMBL2075955 | 0.65 | MAPK14 (1.00) | MAPK14RAF1NTRK1HTR1B | |
| SCHEMBL2073330 | 0.64 | MAPK14 (0.69) | MAPK14RAF1NTRK1HTR1B | |
| SCHEMBL1233622 | 0.64 | MAPK14 (0.68) | MAPK14RAF1 | |
| SCHEMBL1233438 | 0.63 | MAPK14 (0.64) | MAPK14RAF1NTRK1HTR1B | |
| SCHEMBL2074554 | 0.63 | MAPK14 (0.63) | MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009124692-A1 | NEW SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS. | ALMIRALL, S.A. (ES) | 2009-10-15 | — | — | WO | disclosed |