Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3537499 | 0.92 | HRH3 (0.64) | HRH4HRH3SYKNPC1RAB9A | |
| SCHEMBL3538745 | 0.91 | HRH3 (0.66) | HRH4HRH3SYKNPC1RAB9A | |
| SCHEMBL3539676 | 0.91 | HRH3 (0.66) | HRH4HRH3SYKNPC1RAB9A | |
| SCHEMBL3537928 | 0.91 | HRH4 (0.55) | HRH4HRH3HRH1 | |
| SCHEMBL3165702 | 0.90 | HRH4 (0.58) | HRH4HRH3HRH1SYKNPC1 | |
| SCHEMBL3160488 | 0.90 | HRH4 (0.58) | HRH4HRH3HRH1SYKNPC1 | |
| Hydrochloric Acid SCHEMBL3160840 | 0.89 | HRH4 (0.54) | HRH4HRH3SYK | |
| SCHEMBL3534610 | 0.89 | HRH4 (0.57) | HRH4HRH3HRH1SYKNPC1 | |
| SCHEMBL3542031 | 0.89 | HRH3 (0.68) | HRH4HRH3 | |
| SCHEMBL3535196 | 0.88 | HRH3 (0.60) | HRH4HRH3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118059-A1 | 5 -AMIDO- (IH- INDOL- 2 -YL) PIPERAZIN-1-YL-METHANONE DERIVATIVES AS HISTAMINE H3 RECEPTOR LIGANDS | F. Hoffmann-Roche AG (CH) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008095823-A1 | 5 -AMIDO- (IH- INDOL- 2 -YL) PIPERAZIN-1-YL-METHANONE DERIVATIVES AS HISTAMINE H3 RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-14 | — | — | WO | disclosed |