Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Astemizole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 10/20 | 1.00 |
| ▸ | SSTR5 | P35346 | 5/20 | 1.00 |
| ▸ | EED | O75530 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | TACR2 | P21452 | 2/20 | 1.00 |
| ▸ | TACR1 | P25103 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | MLNR | O43193 | 1/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | EGFR | P00533 | 1/20 | 1.00 |
| ▸ | HLA-A | P04439 | 1/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | LCK | P06239 | 1/20 | 1.00 |
| ▸ | FYN | P06241 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Astemizole SCHEMBL1682436 | 0.96 | KCNH2 (0.92) | KCNH2SSTR5HRH1EEDLMNA | |
| SCHEMBL9629272 | 0.96 | EED (1.00) | KCNH2SSTR5HRH1EEDLMNA | |
| Astemizole SCHEMBL8026633 | 0.95 | KCNH2 (0.90) | KCNH2SSTR5HRH1EEDLMNA | |
| SCHEMBL23696974 | 0.95 | KCNH2 (0.90) | KCNH2SSTR5HRH1EEDLMNA | |
| [3H]-Astemizole SCHEMBL30412778 | 0.94 | KCNH2 (0.89) | KCNH2SSTR5HRH1EEDLMNA | |
| [3H]-Astemizole SCHEMBL13109223 | 0.94 | KCNH2 (0.89) | KCNH2SSTR5HRH1EEDLMNA | |
| SCHEMBL12045363 | 0.94 | KCNH2 (0.88) | KCNH2SSTR5HRH1EEDLMNA | |
| Astemizole SCHEMBL6259868 | 0.94 | KCNH2 (0.88) | KCNH2SSTR5HRH1EEDLMNA | |
| SCHEMBL25570238 | 0.93 | SSTR5 (1.00) | KCNH2SSTR5HRH1EEDLMNA | |
| SCHEMBL23696975 | 0.92 | KCNH2 (0.85) | KCNH2SSTR5HRH1EEDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 23267 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436924-B1 | — | — | None | — | — | US | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| WO-2026090421-A1 | APPARATUS, SYSTEMS, AND METHODS FOR ENHANCING CONFIDENCE OF WHEELCHAIR SECUREMENT IN A VEHICLE | VALEDA COMPANY, LLC (US) | 2026-04-30 | — | — | WO | claimed |
| EP-4712925-A1 | PERCEPTION-BASED ALERT SYSTEMS AND CONTROLLERS FOR DETECTING SAFE USE CONDITIONS OF A WHEELCHAIR ACCESS DEVICE IN A WHEELCHAIR ACCESSIBLE VEHICLE | The Braun Corporation (US) | 2026-03-25 | — | — | EP | claimed |
| US-20260069593-A1 | METHODS FOR TREATING CANCER | AMGEN INC (US) | 2026-03-12 | — | — | US | claimed |
| EP-4704971-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| EP-4699655-A2 | COMPOUNDS | TMEM16A LIMITED (GB) | 2026-02-25 | — | — | EP | claimed |
| EP-0190449-B1 | ADDITIVE-CONTAINING PAINTS | OECE Industrie Chimiche Spa (IT) | 1989-08-09 | — | — | EP | claimed |
| EP-0316434-A1 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS. | SUNSHINE ABRAHAM (US) | 1989-05-24 | — | — | EP | claimed |
| US-4829064-A | ACRIVASTINE, ASTEMIZOLE, AZATADINE, CETIRIZINE, KETOTIFIN, LORATIDINE | ANALGESIC ASSOCIATES (US) | 1989-05-09 | — | — | US | claimed |
| EP-0311677-A1 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS. | SUNSHINE ABRAHAM (US) | 1989-04-19 | — | — | EP | claimed |
| WO-1988009656-A1 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS | SUNSHINE ABRAHAM (US) | 1988-12-15 | — | — | WO | claimed |
| US-4783465-A | Cough/cold mixtures comprising non-sedating antihistamine drugs | ANALGESIC ASSOCIATES (US) | 1988-11-08 | — | — | US | claimed |
| WO-1988008302-A1 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS | SUNSHINE ABRAHAM (US) | 1988-11-03 | — | — | WO | claimed |
| US-4778673-A | THERAPEUTIC OR PROPHYLACTIC ACTION TO PREVENT OR NEUTRALIZE IRRITATION OF RESPIRATORY TRACT MUCOSAE; TERPENES; ODORS | OECE INDUSTRIE CHIMICHE SPA (IT) | 1988-10-18 | — | — | US | claimed |
| US-4219559-A | N-Heterocyclyl-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-08-26 | — | — | US | claimed |
| EP-0005318-A1 | N-Heterocyclyl-4-piperidinamines, methods for their preparation, pharmaceutical compositions comprising them, intermediates therefor, and method for the preparation of the intermediates | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-11-14 | — | — | EP | claimed |