Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 6/20 | 0.57 |
| ▸ | ZAP70 | P43403 | 6/20 | 0.57 |
| ▸ | SYK | P43405 | 6/20 | 0.57 |
| ▸ | CDK2 | P24941 | 8/20 | 0.54 |
| ▸ | CDK4 | P11802 | 2/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.53 |
| ▸ | IDH2 | P48735 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 4/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14378974 | 0.88 | SYK (0.73) | SRCZAP70SYKCDK2FLT1 | |
| SCHEMBL14216178 | 0.85 | SYK (0.70) | SRCZAP70SYKCDK2CDK4 | |
| SCHEMBL14216177 | 0.83 | SYK (0.78) | SRCZAP70SYKCDK2CDK4 | |
| SCHEMBL4391357 | 0.83 | CDK2 (0.68) | AURKASRCZAP70SYKCDK2 | |
| SCHEMBL4388095 | 0.83 | CDK2 (0.68) | SRCZAP70SYKCDK2CDK4 | |
| SCHEMBL6362969 | 0.82 | CDK2 (0.76) | AURKACDK2CDK4 | |
| SCHEMBL14378999 | 0.82 | CDK2 (0.64) | AURKASRCZAP70SYKCDK2 | |
| SCHEMBL6156653 | 0.82 | CDK2 (0.72) | AURKACDK2CDK4 | |
| SCHEMBL14008738 | 0.81 | CDK2 (0.51) | AURKASRCZAP70SYKCDK2 | |
| SCHEMBL13924473 | 0.81 | SYK (0.74) | AURKASRCZAP70SYKCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751146-B1 | PYRIDINYL- OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | CYCLACEL LTD (GB) | 2009-12-02 | — | — | EP | claimed |
| EP-1751146-B1 | PYRIDINYL- OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | CYCLACEL LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-20080318954-A1 | Compounds | CYCLACEL LIMITED (GB) | 2008-12-25 | — | — | US | disclosed |
| US-20080318954-A1 | Compounds | CYCLACEL LIMITED (GB) | 2008-12-25 | — | — | US | disclosed |
| US-20080318954-A1 | Compounds | CYCLACEL LIMITED (GB) | 2008-12-25 | — | — | US | disclosed |
| WO-2005075468-A2 | PYRIDINYL - OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | CYCLACEL LIMITED (GB) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318954-A1 | Compounds | CBR3, NR3C2, NR5A1 | AURKA 2935/4885SRC 1992/4885ZAP70 3319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.