Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3983028 | 0.89 | KDM4E (0.72) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL4280638 | 0.88 | KDM4E (0.71) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL14022612 | 0.85 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| Formic Acid SCHEMBL4907287 | 0.84 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL4541684 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL3824964 | 0.84 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| Trifluoroacetic Acid SCHEMBL3815626 | 0.82 | KDM4E (0.59) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL4388671 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL5680266 | 0.81 | KDM4E (0.59) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| Trifluoroacetic Acid SCHEMBL4391023 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1HPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628990-B1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-20070141276-A1 | Novel 14 and 15 membered ring compounds | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | US | disclosed |
| EP-1628990-A1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004101588-A1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2004-11-25 | — | — | WO | disclosed |