SCHEMBL4386220

SCHEMBL4386220

CCC(Cc1ccccc1)c1c[nH]cn1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 2/20 0.42
ESR2 Q92731 2/20 0.42
TRPA1 O75762 1/20 0.38
TAAR1 Q96RJ0 4/20 0.35
SIGMAR1 Q99720 4/20 0.35
SLC6A2 P23975 2/20 0.35
MAOA P21397 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35
CYP2A6 P11509 1/20 0.35
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35
CYP19A1 P11511 1/20 0.34
SLC18A2 Q05940 1/20 0.33
CYP2D6 P10635 1/20 0.33
EPHX1 P07099 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12154823 0.80 ESR1 (0.30) ESR1ESR2
SCHEMBL10547880 0.78 TAAR1 (0.33) ESR1ESR2TAAR1
SCHEMBL224516 0.78 IDO1 (0.39) TRPA1TAAR1SIGMAR1SLC6A2MAOA
SCHEMBL8045920 0.77 CYP19A1 (0.40) ESR1TAAR1SIGMAR1SLC6A2MAOA
SCHEMBL1484177 0.77 SLC6A2 (0.49) TAAR1SIGMAR1SLC6A2MAOASLC6A4
SCHEMBL9570053 0.77 CYP1A2 (0.36) TAAR1SIGMAR1SLC6A2MAOASLC6A4
SCHEMBL225228 0.76 SCN4A (0.35) TRPA1TAAR1SIGMAR1SLC6A2MAOA
SCHEMBL2104158 0.75 CHRM2 (0.41) SLC6A2SLC6A4SLC6A3CYP2D6
SCHEMBL13770256 0.74 CYP19A1 (0.41) TAAR1SIGMAR1SLC6A2MAOASLC6A4
SCHEMBL4389457 0.73 CYP1A2 (0.33) TAAR1SIGMAR1SLC6A2MAOASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248765-B1 ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) 2001-06-19 US claimed
EP-0760811-B1 IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS INST NAT SANTE RECH MED (FR) 2009-11-18 EP disclosed
US-6248765-B1 ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) 2001-06-19 US disclosed
EP-0760811-A1 IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1997-03-12 EP disclosed
WO-1996030048-A1 PROTEIN KINASE C INHIBITORS ELI LILLY AND COMPANY (US) 1996-10-03 WO disclosed
WO-1996029315-A2 IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 1996-09-26 WO disclosed