⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL974046 | 0.97 | — | — | |
| Perchlorate SCHEMBL10416525 | 0.90 | — | — | |
| SCHEMBL926999 | 0.90 | — | — | |
| SCHEMBL19402924 | 0.85 | — | — | |
| SCHEMBL1713705 | 0.74 | — | — | |
| SCHEMBL14295780 | 0.74 | — | — | |
| SCHEMBL14802706 | 0.74 | — | — | |
| SCHEMBL13762579 | 0.72 | — | — | |
| SCHEMBL694584 | 0.72 | — | — | |
| SCHEMBL8252679 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230331770-A1 | ARGININE MODIFICATION AND CONJUGATION METHODS | Encodia, Inc. (US) | 2023-10-19 | — | — | US | disclosed |
| US-20230331770-A1 | ARGININE MODIFICATION AND CONJUGATION METHODS | Encodia, Inc. (US) | 2023-10-19 | — | — | US | disclosed |
| EP-3634964-B1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME (US) | 2022-02-23 | — | — | EP | disclosed |
| US-11028092-B2 | Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-06-08 | — | — | US | disclosed |
| US-10934294-B2 | Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-03-02 | — | — | US | disclosed |
| US-20200140445-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-05-07 | — | — | US | disclosed |
| EP-3634964-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2020-04-15 | — | — | EP | disclosed |
| US-20200054630-A1 | BENZAMIDES-CONTAINING COMPOUNDS AND THEIR USE IN THE TREATMENT OF DEPRESSION | MINDIMMUNE THERAPEUTICS, INC. | 2020-02-20 | — | — | US | disclosed |
| US-20190307766-A1 | CYCLIC AMINES | MINDIMMUNE THERAPEUTICS, INC. | 2019-10-10 | — | — | US | disclosed |
| EP-3536689-A1 | 2-(CYCLIC AMINEETHYL)BENZAMIDE DERIVATIVES AS P2X7 INHIBITORS | MindImmune Therapeutics, Inc. (US) | 2019-09-11 | — | — | EP | disclosed |
| US-20090239870-A1 | Spirohydantoin Aryl Cgrp Receptor Antagonists | MERCK SHARP & DOHME LLC | 2009-09-24 | — | — | US | disclosed |
| WO-2009006959-A1 | PYRIDAZINONE DERIVATES | MERCK PATENT GMBH (DE) | 2009-01-15 | — | — | WO | disclosed |
| US-20080096862-A1 | LACTAM COMPOUNDS AND PHARMACEUTICAL USE THEREOF | AJINOMOTO CO., INC. (JP) | 2008-04-24 | — | — | US | disclosed |
| US-7326701-B2 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2008-02-05 | — | — | US | disclosed |
| WO-2007061677-A2 | SPIROLACTAM ARYL CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007061676-A2 | SPIROHYDANTOIN ARYL CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| US-7153850-B2 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2006-12-26 | — | — | US | disclosed |
| US-20060189597-A1 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2006-08-24 | — | — | US | disclosed |
| US-20040048847-A1 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO. INC (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1346993-A1 | LACTAM COMPOUNDS AND MEDICINAL USE THEREOF | Ajinomoto Co., Inc. (JP) | 2003-09-24 | — | — | EP | disclosed |