Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | GIPR | P48546 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 6/20 | 0.42 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2884636 | 1.00 | GCGR (0.47) | GCGRPTGDR2BRD4GIPRCNR2 | |
| SCHEMBL2883065 | 0.92 | PTGDR2 (0.49) | GCGRPTGDR2BRD4GIPRCNR2 | |
| SCHEMBL2885559 | 0.92 | PTGDR2 (0.49) | GCGRPTGDR2BRD4GIPRCNR2 | |
| SCHEMBL13632823 | 0.92 | PTGDR2 (0.47) | GCGRPTGDR2BRD4GIPRCNR2 | |
| SCHEMBL2883069 | 0.92 | PTGDR2 (0.49) | GCGRPTGDR2BRD4GIPRCNR2 | |
| SCHEMBL2882637 | 0.87 | GCGR (0.58) | GCGRPTGDR2GIPR | |
| SCHEMBL2666811 | 0.87 | GCGR (0.58) | GCGRPTGDR2GIPR | |
| SCHEMBL2666818 | 0.87 | GCGR (0.58) | GCGRPTGDR2GIPR | |
| SCHEMBL2878249 | 0.84 | GCGR (0.45) | GCGRPTGDR2BRD4GIPRCNR2 | |
| SCHEMBL2666584 | 0.84 | GCGR (0.45) | GCGRPTGDR2BRD4GIPRCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765335-B1 | PYRAZOLE AMIDE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-11-25 | — | — | EP | disclosed |