Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 3/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 9/20 | 0.41 |
| ▸ | RET | P07949 | 4/20 | 0.41 |
| ▸ | ROS1 | P08922 | 4/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.36 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL438772 | 0.81 | NTRK1 (0.45) | RHEBNTRK1ACVRL1RETROS1 | |
| SCHEMBL441639 | 0.81 | RHEB (0.45) | RHEBNTRK1ACVRL1RETROS1 | |
| SCHEMBL438749 | 0.81 | RHEB (0.37) | RHEBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL773256 | 0.79 | NTRK1 (0.55) | RHEBNTRK1ACVRL1RETROS1 | |
| SCHEMBL439680 | 0.78 | NTRK1 (0.61) | RHEBNTRK1ACVRL1RETROS1 | |
| SCHEMBL453373 | 0.78 | NTRK1 (0.44) | RHEBNTRK1ACVRL1RETROS1 | |
| SCHEMBL12136084 | 0.77 | NTRK1 (0.44) | RHEBNTRK1ACVRL1RETROS1 | |
| Hydrochloric Acid SCHEMBL3469036 | 0.77 | NTRK1 (0.60) | RHEBNTRK1ACVRL1RETROS1 | |
| SCHEMBL768457 | 0.77 | NTRK1 (0.48) | RHEBNTRK1ACVRL1RETROS1 | |
| SCHEMBL768308 | 0.77 | NTRK1 (0.49) | RHEBNTRK1ACVRL1RETROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822500-B2 | Tyrosine kinase inhibitors | CHEMBRIDGE CORPORATION (US) | 2014-09-02 | — | — | US | disclosed |
| US-8822500-B2 | Tyrosine kinase inhibitors | CHEMBRIDGE CORPORATION (US) | 2014-09-02 | — | — | US | disclosed |
| US-20120065233-A1 | TYROSINE KINASE INHIBITORS | GREGOR VLAD EDWARD (US) | 2012-03-15 | — | — | US | disclosed |
| US-20120065233-A1 | TYROSINE KINASE INHIBITORS | GREGOR VLAD EDWARD (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065233-A1 | TYROSINE KINASE INHIBITORS | ALK, ROS1, ABL1 | RHEB 1830/4885NTRK1 65/4885ACVRL1 592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.