Sugi Predict

Sugi Predict / Compounds / Revefenacin

Revefenacin

Revefenacin

SCHEMBL4387593

CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)c1ccc(CN2CCC(C(N)=O)CC2)cc1.O=P(O)(O)OP(=O)(O)O

nearest known ligand 0.90

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CHRM3

The experimentally established mechanism targets of Revefenacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ CHRM3 known ✓ P20309 19/20 0.53
▸ CHRM2 P08172 1/20 0.90
▸ ADRB2 P07550 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Revefenacin SCHEMBL4387596 0.96 CHRM2 (0.94) CHRM2CHRM3ADRB2
Revefenacin SCHEMBL356480 0.95 CHRM2 (1.00) CHRM2CHRM3ADRB2
SCHEMBL31221643 0.89 CHRM2 (0.88) CHRM2CHRM3ADRB2
SCHEMBL942211 0.89 CHRM2 (0.88) CHRM2CHRM3ADRB2
SCHEMBL24274186 0.88 CHRM2 (0.87) CHRM2CHRM3ADRB2
SCHEMBL10015122 0.88 CHRM2 (0.87) CHRM2CHRM3ADRB2
SCHEMBL942863 0.88 CHRM2 (0.86) CHRM2CHRM3ADRB2
SCHEMBL27870690 0.88 CHRM2 (0.86) CHRM2CHRM3ADRB2
SCHEMBL5959184 0.88 CHRM2 (0.86) CHRM2CHRM3ADRB2
SCHEMBL943273 0.88 CHRM2 (0.85) CHRM2CHRM3ADRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1856050-B1 CRYSTALLINE FORMS OF A BIPHENYL COMPOUND THERAVANCE INC (US) 2009-11-25 — — EP claimed