Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.56 |
| ▸ | JAK3 | P52333 | 6/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | WEE1 | P30291 | 2/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | CCNK | O75909 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 4/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.47 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378959 | 0.86 | JAK2 (0.61) | JAK2JAK3HDAC1HDAC6WEE1 | |
| SCHEMBL4378953 | 0.86 | JAK2 (0.61) | JAK2JAK3HDAC1HDAC6WEE1 | |
| SCHEMBL4376879 | 0.84 | JAK2 (0.77) | JAK2JAK3HDAC1HDAC6WEE1 | |
| SCHEMBL4384824 | 0.84 | JAK2 (0.57) | JAK2JAK3HDAC1HDAC6CDK2 | |
| SCHEMBL4379074 | 0.81 | JAK2 (0.61) | JAK2JAK3HDAC1HDAC6WEE1 | |
| SCHEMBL4380385 | 0.81 | JAK2 (0.53) | JAK2JAK3HDAC1HDAC6WEE1 | |
| SCHEMBL4377784 | 0.79 | JAK2 (0.65) | JAK2JAK3HDAC1HDAC6WEE1 | |
| SCHEMBL4381101 | 0.77 | JAK2 (0.59) | JAK2JAK3HDAC1HDAC6WEE1 | |
| SCHEMBL4380384 | 0.77 | JAK2 (0.59) | JAK2JAK3HDAC1HDAC6WEE1 | |
| SCHEMBL8230904 | 0.76 | JAK2 (0.56) | JAK2JAK3HDAC1HDAC6WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440663-B2 | 4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2013-05-14 | — | — | US | disclosed |
| US-20090298830-A1 | 4-Aryl-2-Amino-Pyrimidnes or 4-Aryl-2-Aminoalkyl-Pyrimidines as Jak-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2009-12-03 | — | — | US | disclosed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298830-A1 | 4-Aryl-2-Amino-Pyrimidnes or 4-Aryl-2-Aminoalkyl-Pyrimidines as Jak-2 Modulators and Methods of Use | JAK2, JAK1, JAK3 | JAK2 1/4885JAK3 3/4885HDAC1 2583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.