Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460351 | 0.84 | TRPV1 (0.66) | TRPV1RAB9ANPC1SMN1; SMN2CASP3 | |
| SCHEMBL4426949 | 0.81 | TRPV1 (0.70) | TRPV1RAB9ANPC1SMN1; SMN2CASP3 | |
| SCHEMBL4386179 | 0.80 | TRPV1 (0.61) | TRPV1RAB9ANPC1SMN1; SMN2CASP3 | |
| SCHEMBL4386399 | 0.80 | TRPV1 (0.63) | TRPV1RAB9ANPC1SMN1; SMN2CASP3 | |
| SCHEMBL4388633 | 0.79 | TRPV1 (1.00) | TRPV1RAB9ANPC1SMN1; SMN2CASP3 | |
| SCHEMBL29386356 | 0.79 | TRPV1 (1.00) | TRPV1RAB9ANPC1SMN1; SMN2CASP3 | |
| SCHEMBL4425329 | 0.78 | TRPV1 (0.67) | TRPV1RAB9ANPC1SMN1; SMN2CASP3 | |
| SCHEMBL4389994 | 0.78 | TRPV1 (0.74) | TRPV1RAB9ANPC1SMN1; SMN2CASP3 | |
| SCHEMBL5128895 | 0.76 | TRPV1 (0.78) | TRPV1RAB9ANPC1SMN1; SMN2CASP3 | |
| SCHEMBL4384830 | 0.75 | TRPV1 (0.62) | TRPV1RAB9ANPC1SMN1; SMN2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606289-B1 | CARBOXAMIDE DERIVATIVES | GLAXO GROUP LTD (GB) | 2009-12-02 | — | — | EP | claimed |
| EP-1606289-B1 | CARBOXAMIDE DERIVATIVES | GLAXO GROUP LTD (GB) | 2009-12-02 | — | — | EP | disclosed |