Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4380646 | 0.99 | KDM4E (0.55) | KDM4EALDH1A1CHRM1MAPTHIF1A | |
| SCHEMBL3859810 | 0.77 | KDM4E (0.64) | KDM4EALDH1A1CHRM1POLB | |
| SCHEMBL4377352 | 0.75 | HRH3 (0.76) | KDM4EALDH1A1MAPTHIF1AHRH3 | |
| Hydrochloric Acid SCHEMBL4377272 | 0.74 | HRH3 (0.77) | KDM4EALDH1A1MAPTHIF1AHRH3 | |
| SCHEMBL13636480 | 0.73 | HRH3 (0.65) | KDM4EALDH1A1MAPTHIF1AHRH3 | |
| SCHEMBL16705050 | 0.72 | KDM4E (0.57) | KDM4EALDH1A1CHRM1HRH3POLB | |
| SCHEMBL469112 | 0.72 | KDM4E (0.57) | KDM4EALDH1A1CHRM1HRH3POLB | |
| SCHEMBL4375964 | 0.72 | HRH3 (0.65) | KDM4EALDH1A1CHRM1HRH3TSHR | |
| SCHEMBL13004966 | 0.71 | NPSR1 (0.67) | KDM4EALDH1A1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL4375732 | 0.71 | HRH3 (0.65) | KDM4EALDH1A1CHRM1HRH3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |