Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.34 |
| ▸ | PDE4A | P27815 | 6/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5950136 | 0.88 | MAPT (0.43) | L3MBTL1ALDH1A1PDE4DPDE4BPDE4A | |
| SCHEMBL28526123 | 0.79 | HTT (0.39) | ALDH1A1MEN1KMT2AMAPTNR1I2 | |
| SCHEMBL4126031 | 0.78 | PDE4D (0.61) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL4286299 | 0.77 | TDP1 (0.33) | L3MBTL1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1202997 | 0.77 | PDE4D (0.44) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7421344 | 0.76 | CA1 (0.36) | L3MBTL1ALDH1A1PDE4DPDE4BPDE4A | |
| SCHEMBL27740994 | 0.73 | MAPT (0.54) | L3MBTL1ALDH1A1PDE4DPDE4BPDE4A | |
| SCHEMBL29997568 | 0.69 | TDP1 (0.44) | ALDH1A1PDE4DMAPTTDP1POLB | |
| SCHEMBL2202238 | 0.69 | TDP1 (0.44) | ALDH1A1PDE4DMAPTTDP1POLB | |
| SCHEMBL222062 | 0.68 | MAPT (0.55) | L3MBTL1ALDH1A1PDE4DMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090171096-A1 | Novel process for the preparation of roflumilast | NYCOMED GMBH (DE) | 2009-07-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090171096-A1 | Novel process for the preparation of roflumilast | PLAT, VASP, F2R | L3MBTL1 4867/4885ALDH1A1 1080/4885PDE4D 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.