Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 19/20 | 0.54 |
| ▸ | PPARA | Q07869 | 19/20 | 0.54 |
| ▸ | PPARD | Q03181 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4391370 | 0.97 | PPARG (0.56) | PPARGPPARAPPARDCYP1A2 | |
| SCHEMBL4391319 | 0.96 | PPARG (0.58) | PPARGPPARAPPARDCYP1A2 | |
| SCHEMBL4392767 | 0.96 | PPARG (0.57) | PPARGPPARAPPARDCYP1A2 | |
| SCHEMBL4392775 | 0.96 | PPARG (0.57) | PPARGPPARAPPARDCYP1A2 | |
| SCHEMBL4394243 | 0.94 | PPARG (0.51) | PPARGPPARAPPARDCYP1A2 | |
| SCHEMBL4398630 | 0.90 | PPARG (0.53) | PPARGPPARAPPARD | |
| SCHEMBL5652514 | 0.90 | PPARG (0.51) | PPARGPPARAPPARDCYP1A2 | |
| SCHEMBL4392769 | 0.89 | PPARG (0.55) | PPARGPPARAPPARD | |
| SCHEMBL4392770 | 0.88 | PPARG (0.54) | PPARGPPARAPPARD | |
| SCHEMBL13591559 | 0.86 | PPARG (0.46) | PPARGPPARAPPARDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067109-B1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2009-12-09 | — | — | EP | disclosed |
| EP-1067109-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-10 | — | — | EP | disclosed |