SCHEMBL4389915

SCHEMBL4389915

CC(C)(O)CC[C@H](C[C@H](O)[C@@H](N)Cc1cc(F)cc(F)c1)C(N)=O

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 7/20 0.48
CHRM2 P08172 1/20 0.48
CCR5 P51681 1/20 0.48
REN P00797 1/20 0.34
EPHX1 P07099 1/20 0.33
BACE1 P56817 6/20 0.32
CTSD P07339 3/20 0.32
DPP4 P27487 1/20 0.32
FNTA P49354 2/20 0.31
FNTB P49356 2/20 0.31
PGGT1B P53609 2/20 0.31
ADRB1 P08588 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4071147 0.91 CCR1 (0.43) CCR1CHRM2CCR5RENEPHX1
SCHEMBL3825745 0.89 CCR1 (0.60) CCR1CHRM2CCR5RENDPP4
SCHEMBL2676428 0.89 CCR1 (0.60) CCR1CHRM2CCR5RENDPP4
SCHEMBL4062769 0.87 CCR1 (0.40) CCR1CHRM2CCR5REN
SCHEMBL2677149 0.85 CCR1 (0.46) CCR1CHRM2CCR5RENDPP4
SCHEMBL2675073 0.83 CCR1 (0.57) CCR1CHRM2CCR5
SCHEMBL2676715 0.80 CCR1 (0.47) CCR1CHRM2CCR5REN
SCHEMBL4067311 0.80 CCR1 (0.48) CCR1CHRM2CCR5RENEPHX1
SCHEMBL4062779 0.80 CCR1 (0.51) CCR1CHRM2CCR5RENDPP4
SCHEMBL2676322 0.79 CCR1 (0.60) CCR1CHRM2CCR5RENDPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0966443-B1 HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR PFIZER (US) 2009-01-28 EP disclosed
US-6403587-B1 AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND PFIZER INC. 2002-06-11 US disclosed
EP-0966443-A1 HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR PFIZER INC. (US) 1999-12-29 EP disclosed
WO-1998038167-A1 HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR PFIZER INC. (US) 1998-09-03 WO disclosed