Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 9/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10666298 | 0.92 | ABCB1 (0.61) | ABCB1KMT2AMAOAMAOBSLC6A4 | |
| SCHEMBL10315942 | 0.85 | ABCB1 (1.00) | ABCB1KDM4EGAAMAPTRAB9A | |
| SCHEMBL10278367 | 0.85 | ABCB1 (0.74) | ABCB1KDM4EGAAMAPTRAB9A | |
| SCHEMBL2792311 | 0.85 | ABCB1 (0.74) | ABCB1KDM4EGAAMAPTRAB9A | |
| SCHEMBL2769113 | 0.84 | ABCB1 (0.68) | ABCB1KDM4EGAAMAPTRAB9A | |
| SCHEMBL23001345 | 0.84 | ABCB1 (0.97) | ABCB1KDM4EGAAMAPTRAB9A | |
| SCHEMBL4228297 | 0.84 | ABCB1 (0.76) | ABCB1KDM4EGAAMAPTRAB9A | |
| Hydrochloric Acid SCHEMBL2137481 | 0.84 | ABCB1 (0.72) | ABCB1KDM4EGAAMAPTRAB9A | |
| Hydrochloric Acid SCHEMBL4256189 | 0.84 | ABCB1 (0.72) | ABCB1KDM4EGAAMAPTRAB9A | |
| SCHEMBL29634116 | 0.84 | ABCB1 (0.76) | ABCB1KDM4EGAAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144405-B1 | TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY | ABBOTT GMBH & CO KG (DE) | 2009-11-25 | — | — | EP | disclosed |
| US-6602867-B1 | Triazole compounds with dopamine-D3-receptor affinity | ABBOTT LABORATORIES | 2003-08-05 | — | — | US | disclosed |
| US-5565470-A | HYPOTENSIVE OR ANTIARRHYTHMIA AGENTS, ALSO FOR TREATMENT OF ANGINA OR GLAUCOMA | SANOFI (FR) | 1996-10-15 | — | — | US | disclosed |
| US-5340820-A | Useful for treatment of ocular diseases, angina pectoris, hypertension and arrhythmia | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |