Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 8/20 | 0.76 |
| ▸ | FLT3 | P36888 | 8/20 | 0.76 |
| ▸ | SYK | P43405 | 8/20 | 0.65 |
| ▸ | AURKA | O14965 | 5/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.64 |
| ▸ | JAK2 | O60674 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 1/20 | 0.60 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | BMX | P51813 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.60 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4391016 | 1.00 | KIT (0.76) | KITFLT3SYKAURKAAURKB | |
| SCHEMBL12082959 | 1.00 | KIT (0.76) | KITFLT3SYKAURKAAURKB | |
| SCHEMBL14607406 | 0.91 | SYK (0.74) | KITFLT3SYKAURKAAURKB | |
| SCHEMBL28519550 | 0.86 | FLT3 (1.00) | KITFLT3AURKAEGFRNTRK1 | |
| SCHEMBL28522032 | 0.86 | FLT3 (1.00) | KITFLT3AURKAEGFRNTRK1 | |
| SCHEMBL20336254 | 0.85 | KIT (0.58) | KITFLT3SYKAURKAAURKB | |
| SCHEMBL20336253 | 0.85 | KIT (0.58) | KITFLT3SYKAURKAAURKB | |
| SCHEMBL3496536 | 0.81 | AURKA (0.58) | KITFLT3SYKAURKAAURKB | |
| SCHEMBL4374317 | 0.80 | SYK (0.79) | SYKALK | |
| SCHEMBL12082995 | 0.80 | SYK (0.79) | SYKALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298823-A1 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | US | claimed |
| US-9139581-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-20130029944-A1 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-01-31 | — | — | US | disclosed |
| US-8258144-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-09-04 | — | — | US | disclosed |
| US-20090298823-A1 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130029944-A1 | INHIBITORS OF PROTEIN KINASES | SYK, BTK, JAK2 | KIT 175/4885FLT3 18/4885SYK 1/4885 |
| US-20090298823-A1 | Inhibitors of protein kinases | SYK, BTK, JAK2 | KIT 175/4885FLT3 18/4885SYK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.