Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mardepodect. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A known ✓ | Q9Y233 | 18/20 | 0.86 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.86 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.86 |
| ▸ | PDE4A | P27815 | 7/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mardepodect SCHEMBL29430177 | 1.00 | PDE10A (0.86) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| SCHEMBL30123358 | 0.93 | PDE10A (1.00) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| SCHEMBL3271928 | 0.93 | PDE10A (1.00) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| Mardepodect SCHEMBL29496270 | 0.93 | PDE10A (1.00) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| Mardepodect SCHEMBL1414700 | 0.93 | PDE10A (1.00) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| Mardepodect SCHEMBL29435412 | 0.92 | PDE10A (0.98) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| Mardepodect SCHEMBL30357427 | 0.92 | PDE10A (0.98) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| SCHEMBL13772734 | 0.88 | PDE10A (0.86) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| SCHEMBL4870859 | 0.86 | PDE10A (0.86) | PDE10ALGALS3PDE4DPDE4APDE4B | |
| Succinic Acid SCHEMBL441548 | 0.85 | PDE10A (0.87) | PDE10ALGALS3PDE4DPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295731-A | Prodrugs of PDE10 compounds | 默沙东有限责任公司 | 2023-12-26 | — | — | CN | disclosed |
| EP-2763533-B1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2021-12-29 | — | — | EP | disclosed |
| EP-2435048-B1 | RADIOLABELED PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2019-07-03 | — | — | EP | disclosed |
| EP-2785183-B1 | TRIAZOLOPYRIDINONE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-12-19 | — | — | EP | disclosed |
| EP-2922823-B1 | PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-10-31 | — | — | EP | disclosed |
| EP-2968324-B1 | SUBSTITUTED PYRIDAZINONE DERIVATIVES AS PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-04-18 | — | — | EP | disclosed |
| EP-2919783-B1 | CYCLOPROPYL IMIDAZOPYRIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-01-31 | — | — | EP | disclosed |
| EP-2621276-B1 | 2-ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-12-27 | — | — | EP | disclosed |
| EP-2621926-B1 | PYRAZOLOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-08-30 | — | — | EP | disclosed |
| EP-2919781-B1 | CYCLOBUTYL BENZIMIDAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2012058133-A1 | ISOINDOLINONE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012054366-A2 | SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012044561-A2 | 2-ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |
| US-20120064005-A1 | RADIOLABELED PDE10 INHIBITORS | MERCK SHARP & DOHME LLC | 2012-03-15 | — | — | US | disclosed |
| US-20120065211-A1 | ALKOXY TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. | 2012-03-15 | — | — | US | disclosed |
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | COX CHRISTOPHER D (US) | 2011-12-29 | — | — | US | disclosed |
| WO-2011053559-A1 | ARYL AMINOPYRIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-05-05 | — | — | WO | disclosed |
| WO-2010138585-A1 | PYRIMIDINONES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138430-A1 | ALKOXY TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138577-A1 | RADIOLABELED PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065211-A1 | ALKOXY TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | PDE12, PDE4A, PDE5A | PDE10A 6/4885LGALS3 4492/4885PDE4D 8/4885 |
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | PDE5A, PDE12, PDE7B | PDE10A 10/4885LGALS3 4738/4885PDE4D 13/4885 |
| US-20120064005-A1 | RADIOLABELED PDE10 INHIBITORS | PDE5A, PDE3A, PDE10A | PDE10A 3/4885LGALS3 4493/4885PDE4D 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.