Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 14/20 | 0.36 |
| ▸ | PPARG | P37231 | 12/20 | 0.36 |
| ▸ | PPARD | Q03181 | 4/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377325 | 0.96 | PPARA (0.39) | PPARAPPARGPPARDS1PR4S1PR1 | |
| SCHEMBL4478212 | 0.96 | PPARA (0.39) | PPARAPPARGPPARDS1PR4S1PR1 | |
| SCHEMBL4381987 | 0.89 | PPARA (0.41) | PPARAPPARGPPARD | |
| SCHEMBL4475020 | 0.89 | PPARA (0.41) | PPARAPPARGPPARD | |
| SCHEMBL4388898 | 0.89 | PPARA (0.37) | PPARAPPARGPPARDNPSR1 | |
| SCHEMBL4382593 | 0.89 | PPARA (0.37) | PPARAPPARGPPARDNPSR1 | |
| SCHEMBL4380740 | 0.89 | PPARA (0.45) | PPARAPPARGPPARDS1PR4S1PR1 | |
| SCHEMBL4386898 | 0.89 | PPARA (0.45) | PPARAPPARGPPARDS1PR4S1PR1 | |
| SCHEMBL4380913 | 0.88 | PPARA (0.46) | PPARAPPARGPPARDNPSR1 | |
| SCHEMBL4380920 | 0.88 | PPARA (0.46) | PPARAPPARGPPARDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789402-B1 | 2-{-3-2-(PHENYL)-OXAZOL-4-YLMETHOXYMETHYL!-CYCLOHEXYLMETHOXY };-PROPIONIC ACID DERIVATIVES USED AS PPAR LIGANDES (PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS) FOR THE TREATMENT OF HYPERLIPIDAEMIE AND DIABETES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-11-18 | — | — | EP | disclosed |