Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 3/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907582 | 0.99 | GSK3B (0.44) | GSK3BCA1CA2KDM4EALDH1A1 | |
| SCHEMBL13591424 | 0.90 | KDM4E (0.43) | GSK3BCA1CA2KDM4EALDH1A1 | |
| SCHEMBL4388089 | 0.83 | KDM4E (0.43) | GSK3BCA1CA2KDM4EALDH1A1 | |
| SCHEMBL4387147 | 0.82 | HRH3 (0.48) | GSK3BKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL4908453 | 0.82 | KDM4E (0.42) | GSK3BCA1CA2KDM4EALDH1A1 | |
| SCHEMBL3819280 | 0.81 | KDM4E (0.53) | GSK3BCA1CA2KDM4EALDH1A1 | |
| SCHEMBL5550927 | 0.81 | KDM4E (0.50) | GSK3BCA1CA2KDM4EALDH1A1 | |
| SCHEMBL3819196 | 0.80 | KDM4E (0.52) | GSK3BCA1CA2KDM4EALDH1A1 | |
| SCHEMBL13997267 | 0.78 | KDM4E (0.46) | GSK3BCA1CA2KDM4EALDH1A1 | |
| SCHEMBL3819773 | 0.78 | KDM4E (0.44) | GSK3BCA1CA2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628990-B1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-20070141276-A1 | Novel 14 and 15 membered ring compounds | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | US | disclosed |