Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 14/20 | 0.70 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | WEE1 | P30291 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1674229 | 0.92 | MAPKAPK5 (0.82) | MAPKAPK5FYNFLT3 | |
| SCHEMBL14387682 | 0.89 | MAPKAPK5 (0.69) | MAPKAPK5FYNFLT3WEE1 | |
| SCHEMBL1674239 | 0.83 | MAPKAPK5 (0.58) | MAPKAPK5FYNWEE1ALK | |
| SCHEMBL4392693 | 0.83 | MAPKAPK5 (0.68) | MAPKAPK5FYN | |
| SCHEMBL2068531 | 0.82 | MAPKAPK5 (1.00) | MAPKAPK5FYNFLT3 | |
| SCHEMBL1674168 | 0.80 | MAPKAPK5 (0.61) | MAPKAPK5FYNFLT3BRD4 | |
| SCHEMBL1674362 | 0.78 | MAPKAPK5 (0.83) | MAPKAPK5FYNFLT3ALKBRD4 | |
| SCHEMBL2070836 | 0.78 | MAPKAPK5 (0.81) | MAPKAPK5FYN | |
| SCHEMBL4387555 | 0.78 | MAPKAPK5 (0.66) | MAPKAPK5FYNBRD4 | |
| SCHEMBL1674183 | 0.77 | MAPKAPK5 (0.63) | MAPKAPK5FYNWEE1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027124-A1 | IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | Galapagos N.V. (BE) | 2009-02-25 | — | — | EP | claimed |
| WO-2007131991-A1 | IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2007-11-22 | — | — | WO | claimed |