Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10569038 | 1.00 | PDE4A (0.47) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL4391330 | 1.00 | PDE4A (0.47) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL4654770 | 1.00 | PDE4A (0.47) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL15518885 | 0.96 | PDE4A (0.47) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL8740477 | 0.96 | PDE4A (0.47) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL1119100 | 0.94 | PDE4A (0.42) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL3039763 | 0.94 | PDE4A (0.42) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL2365648 | 0.94 | PDE4A (0.42) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL3919093 | 0.94 | PDE4A (0.42) | PDE4ALMNAL3MBTL1TDP1USP2 | |
| SCHEMBL4393059 | 0.93 | PDE4A (0.47) | PDE4ALMNAL3MBTL1TDP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10175233-B2 | Biomarkers for cardiovascular diseases and methods using the same | METABOLON, INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20160178620-A1 | Biomarkers for Pre-Diabetes, Cardiovascular Diseases, and other Metabolic-Syndrome Related Disorders and Methods Using the Same | METABOLON, INC. | 2016-06-23 | — | — | US | disclosed |
| US-9250225-B2 | Biomarkers for insulin resistance and methods using the same | METABOLON, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150005195-A1 | Biomarkers for Pre-Diabetes, Cardiovascular Diseases, and Other Metabolic-Syndrome Related Disorders and Methods Using the Same | METABOLON, INC. | 2015-01-01 | — | — | US | disclosed |
| US-8809008-B2 | Biomarkers for impaired glucose tolerance and methods using the same | METABOLON, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20130338031-A1 | Biomarkers for Pre-Diabetes, Cardiovascular Diseases, and Other Metabolic-Syndrome Related Disorders and Methods Using the Same | METABOLON, INC. | 2013-12-19 | — | — | US | disclosed |
| EP-2164977-B1 | BIOMARKERS FOR PRE-DIABETES AND METHODS USING THE SAME | METABOLON INC (US) | 2013-10-30 | — | — | EP | disclosed |
| US-8546098-B2 | Biomarkers for monitoring insulin resistance and methods using the same | METABOLON, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20120208215-A1 | Biomarkers for Pre-Diabetes, Cardiovascular Diseases, and Other Metabolic-Syndrome Related Disorders and Methods Using the Same | METABOLON, INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-8187830-B2 | Method for determining insulin sensitivity with biomarkers | METABOLON, INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090155826-A1 | Biomarkers for pre-diabetes, cardiovascular diseases, and other metabolic-syndrome related disorders and methods using the same | METABOLON, INC. (US) | 2009-06-18 | — | — | US | disclosed |