Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | PDE7A | Q13946 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.37 |
| ▸ | S100A10 | P60903 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31165423 | 0.83 | MAPT (0.70) | MAPTCYP3A4TSHRMAPK1PDE7A | |
| SCHEMBL8384783 | 0.82 | MAPT (0.44) | MAPTCYP3A4MAPK1MEN1KMT2A | |
| SCHEMBL12102886 | 0.81 | CXCL12 (0.46) | MAPTCYP3A4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2989224 | 0.80 | MAPT (0.43) | MAPTCYP3A4PDE7AMEN1KMT2A | |
| SCHEMBL12935505 | 0.79 | MAPT (1.00) | MAPTCYP3A4TSHRMAPK1PDE7A | |
| SCHEMBL10560991 | 0.77 | TSHR (0.54) | MAPTCYP3A4TSHRMAPK1PDE7A | |
| SCHEMBL10522332 | 0.76 | CYP3A4 (0.48) | MAPTCYP3A4TSHRMAPK1PDE7A | |
| SCHEMBL4394095 | 0.76 | CHEK2 (0.45) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL829690 | 0.72 | KDM1A (0.59) | MAPTCYP3A4TSHRMAPK1PDE7A | |
| SCHEMBL1532386 | 0.72 | SIRT2 (0.45) | MAPTCYP3A4MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130066069-A1 | PROCESSES FOR PREPARING SUBSTITUTED PYRIMIDINES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-03-14 | — | — | US | disclosed |
| US-20090298844-A1 | ABL KINASE INHIBITION | VERTEX PHARMACEUTICALS INCORPORATED | 2009-12-03 | — | — | US | disclosed |
| WO-2007136615-A2 | COMBINATION CANCER THERAPY | MERCK & CO., INC. (US) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298844-A1 | ABL KINASE INHIBITION | ABL2, ABL1, PRKDC | MAPT 2896/4885CYP3A4 4276/4885TSHR 3282/4885 |
| US-20130066069-A1 | PROCESSES FOR PREPARING SUBSTITUTED PYRIMIDINES | AURKA, AURKC, AURKB | MAPT 982/4885CYP3A4 2192/4885TSHR 3178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.