Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.92 |
| ▸ | POLB | P06746 | 4/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559772 | 0.98 | HTT (0.88) | HTTPOLBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL13380 | 0.96 | HTT (1.00) | HTTPOLBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL679199 | 0.96 | HTT (1.00) | HTTPOLBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL8396675 | 0.96 | HTT (1.00) | HTTPOLBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL8395096 | 0.96 | HTT (1.00) | HTTPOLBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL8392088 | 0.96 | HTT (1.00) | HTTPOLBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL25708013 | 0.96 | HTT (1.00) | HTTPOLBHSD17B10KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL27819236 | 0.94 | HTT (0.96) | HTTPOLBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL27979494 | 0.93 | HTT (0.88) | HTTPOLBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL8391614 | 0.93 | HTT (0.96) | HTTPOLBHSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620395-B1 | AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS | VERNALIS RES LTD (GB) | 2009-12-30 | — | — | EP | disclosed |
| EP-1620395-A1 | AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS | VERNALIS RESEARCH LIMITED (GB) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004096763-A1 | AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS | VERNALIS RESEARCH LIMITED (GB) | 2004-11-11 | — | — | WO | disclosed |