Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.31 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.31 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL4391463 | 1.00 | SLC7A5 (0.43) | SLC7A5SLC1A3SLC1A2RENSLC1A1 | |
| Leucine SCHEMBL4397081 | 1.00 | SLC7A5 (0.43) | SLC7A5SLC1A3SLC1A2RENSLC1A1 | |
| Leucine SCHEMBL29090979 | 0.95 | SLC7A5 (0.47) | SLC7A5SLC1A3SLC1A2SLC1A1NOS2 | |
| Leucine SCHEMBL4612424 | 0.94 | SLC7A5 (0.49) | SLC7A5SLC1A3SLC1A2RENSLC1A1 | |
| Leucine SCHEMBL21382169 | 0.94 | SLC7A5 (0.49) | SLC7A5SLC1A3SLC1A2RENSLC1A1 | |
| Leucine SCHEMBL23091356 | 0.94 | SLC7A5 (0.49) | SLC7A5SLC1A3SLC1A2RENSLC1A1 | |
| Leucine SCHEMBL3089172 | 0.94 | SLC7A5 (0.49) | SLC7A5SLC1A3SLC1A2RENSLC1A1 | |
| Leucine SCHEMBL5889661 | 0.94 | SLC7A5 (0.49) | SLC7A5SLC1A3SLC1A2RENSLC1A1 | |
| Leucine SCHEMBL1675456 | 0.94 | SLC7A5 (0.49) | SLC7A5SLC1A3SLC1A2RENSLC1A1 | |
| Leucine SCHEMBL28392735 | 0.94 | SLC7A5 (0.49) | SLC7A5SLC1A3SLC1A2RENSLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11384117-B2 | Connective tissue stimulating peptides | OCTANE ORTHOBIOLOGICS INC. (CA) | 2022-07-12 | — | — | US | disclosed |
| US-20190077831-A1 | CONNECTIVE TISSUE STIMULATING PEPTIDES | MILLENIUM BIOLOGIX INC. (CA) | 2019-03-14 | — | — | US | disclosed |
| US-10202419-B2 | Connective tissue stimulating peptides | OCTANE ORTHOBIOLOGICS INC. (CA) | 2019-02-12 | — | — | US | disclosed |
| US-20160237117-A1 | CONNECTIVE TISSUE STIMULATING PEPTIDES | MILLENIUM BIOLOGIX INC. (CA) | 2016-08-18 | — | — | US | disclosed |
| US-9133236-B2 | Connective tissue stimulating peptides | MILLENIUM BIOLOGIX INC. (CA) | 2015-09-15 | — | — | US | disclosed |
| US-20120156276-A1 | Connective tissue stimulating peptides | MILLENIUM BIOLOGIX INC. (CA) | 2012-06-21 | — | — | US | disclosed |
| US-7491691-B2 | Connective tissue stimulating peptides | OCTANE ORTHOBIOLOGICS INC. (CA) | 2009-02-17 | — | — | US | disclosed |
| US-20050288229-A1 | Connective Tissue Stimulating Peptides | MILLENIUM BIOLOGIX INC. (CA) | 2005-12-29 | — | — | US | disclosed |
| EP-1504033-A2 | CONNECTIVE TISSUE STIMULATING PEPTIDES | MILLENIUM BIOLOGIX INC. (CA) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003093314-A2 | CONNECTIVE TISSUE STIMULATING PEPTIDES | MILLENIUM BIOLOGIX INC. (CA) | 2003-11-13 | — | — | WO | disclosed |