Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.68 |
| ▸ | PLK3 | Q9H4B4 | 15/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | CDK2 | P24941 | 1/20 | 0.64 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | PIM1 | P11309 | 2/20 | 0.59 |
| ▸ | NEK2 | P51955 | 2/20 | 0.59 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.54 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.54 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4404346 | 0.94 | PLK1 (0.67) | PLK1PLK3CYP2C9CYP3A4CDK2 | |
| SCHEMBL14029665 | 0.91 | PLK1 (0.71) | PLK1PLK3CYP2C9CYP3A4CDK2 | |
| SCHEMBL14029654 | 0.90 | PLK1 (0.69) | PLK1PLK3CYP2C9CYP3A4CDK2 | |
| SCHEMBL2977906 | 0.89 | PLK1 (0.74) | PLK1PLK3CYP2C9CYP3A4CDK2 | |
| SCHEMBL13206398 | 0.89 | PLK1 (0.74) | PLK1PLK3CYP2C9CYP3A4CDK2 | |
| Trifluoroacetic Acid SCHEMBL5003083 | 0.87 | PLK1 (0.65) | PLK1PLK3CYP2C9CDK2IKBKE | |
| SCHEMBL4398315 | 0.87 | PLK1 (0.65) | PLK1PLK3CYP2C9CYP3A4CDK2 | |
| Trifluoroacetic Acid SCHEMBL5003812 | 0.86 | PLK1 (0.64) | PLK1PLK3CYP2C9CDK2IKBKE | |
| SCHEMBL14029667 | 0.86 | PLK1 (0.64) | PLK1PLK3CYP2C9CYP3A4CDK2 | |
| SCHEMBL4405087 | 0.86 | PLK1 (0.74) | PLK1PLK3CYP2C9CYP3A4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-B1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORP (US) | 2009-12-30 | — | — | EP | disclosed |
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | SMITHKLINE BEECHAM CORPORATION | 2008-10-09 | — | — | US | disclosed |
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | SMITHKLINE BEECHAM CORPORATION | 2008-10-09 | — | — | US | disclosed |
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | SMITHKLINE BEECHAM CORPORATION | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | CYP3A4, CYP2C19, CYP2B6 | PLK1 1718/4885PLK3 2097/4885CYP2C9 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.