Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.69 |
| ▸ | PLK3 | Q9H4B4 | 15/20 | 0.69 |
| ▸ | NEK2 | P51955 | 4/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.69 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.69 |
| ▸ | PIM1 | P11309 | 2/20 | 0.69 |
| ▸ | KDR | P35968 | 2/20 | 0.69 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977487 | 0.90 | PLK1 (0.70) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4999529 | 0.90 | PLK1 (0.56) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL2986655 | 0.89 | PLK1 (0.85) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4632790 | 0.89 | PLK1 (0.56) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4397830 | 0.89 | PLK1 (0.73) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL5002745 | 0.88 | PLK1 (0.55) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL5003021 | 0.87 | PLK1 (0.52) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4398007 | 0.87 | PLK1 (0.72) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL2980517 | 0.87 | PLK1 (0.72) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4999361 | 0.86 | PLK1 (0.53) | PLK1PLK3NEK2PIK3CDNUAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937671-B1 | BENZIMIDAZOLE THIOPHENE COMPOUNDS AS PLK INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2009-12-16 | — | — | EP | disclosed |