Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 15/20 | 0.51 |
| ▸ | BRAF | P15056 | 14/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4400279 | 1.00 | SYK (0.65) | SYKLCKKDRJAK3MAPK14 | |
| SCHEMBL10043783 | 1.00 | SYK (0.65) | SYKLCKKDRJAK3MAPK14 | |
| SCHEMBL10072195 | 0.92 | SYK (0.62) | SYKLCKKDRJAK3MAPK14 | |
| SCHEMBL10043807 | 0.92 | SYK (0.62) | SYKLCKKDRJAK3MAPK14 | |
| SCHEMBL14217457 | 0.92 | SYK (0.54) | SYKLCKKDRJAK3MAPK14 | |
| SCHEMBL10043786 | 0.91 | SYK (0.66) | SYKLCKKDRJAK3MAPK14 | |
| SCHEMBL10043789 | 0.90 | SYK (0.61) | SYKLCKKDRJAK3MAPK14 | |
| SCHEMBL10043817 | 0.90 | SYK (0.61) | SYKLCKKDRJAK3MAPK14 | |
| SCHEMBL10072196 | 0.90 | SYK (0.60) | SYKLCKKDRJAK3MAPK14 | |
| SCHEMBL10072213 | 0.90 | SYK (0.60) | SYKLCKKDRJAK3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528744-A | Compositions and methods for modulating C-KIT and PDGFR receptors | IRM LLC (VG) | 2009-09-09 | — | — | CN | disclosed |
| EP-2076513-A1 | COMPOSITIONS AND METHODS FOR MODULATING C-KIT AND PDGFR RECEPTORS | IRM LLC (BM) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008051757-A1 | COMPOSITIONS AND METHODS FOR MODULATING C-KIT AND PDGFR RECEPTORS | IRM LLC (BM) | 2008-05-02 | — | — | WO | disclosed |