Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 19/20 | 0.72 |
| ▸ | EGFR | P00533 | 3/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083320 | 0.88 | ERBB2 (0.76) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL4083330 | 0.88 | ERBB2 (0.76) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL4075477 | 0.85 | ERBB2 (0.74) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL3376620 | 0.85 | ERBB2 (0.88) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL3376323 | 0.85 | ERBB2 (0.81) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL3376295 | 0.85 | ERBB2 (0.88) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL3376361 | 0.84 | ERBB2 (0.70) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL3376358 | 0.84 | ERBB2 (0.74) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL3376439 | 0.84 | ERBB2 (1.00) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL3376637 | 0.84 | ERBB2 (1.00) | ERBB2EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877398-B1 | QUINAZOLINE DERIVATIVES AS EGF AND/OR ERBB2 TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-08-05 | — | — | EP | disclosed |