Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 17/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 14/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 13/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 12/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | FYN | P06241 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | PRKACG | P22612 | 1/20 | 0.50 |
| ▸ | PRKACB | P22694 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399122 | 0.97 | FGFR4 (0.56) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4398606 | 0.95 | FGFR4 (0.52) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4411713 | 0.95 | FGFR4 (0.51) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4405612 | 0.94 | FGFR4 (0.61) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL4398033 | 0.92 | FGFR4 (0.53) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4404876 | 0.92 | FGFR4 (0.51) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4412895 | 0.91 | FGFR4 (0.53) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL4405610 | 0.91 | FGFR4 (0.62) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL4409287 | 0.91 | FGFR4 (0.50) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4398355 | 0.91 | FGFR1 (0.56) | FGFR4FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549651-B1 | PYRIMIDOPYRIMIDONES AS KINASE INHIBITORS | WARNER LAMBERT CO (US) | 2009-12-23 | — | — | EP | disclosed |
| US-7196090-B2 | Kinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2007-03-27 | — | — | US | disclosed |
| EP-1549651-A1 | KINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011465-A1 | KINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-05 | — | — | WO | disclosed |
| US-20040019210-A1 | Kinase inhibitors | CHIVIKAS CONNOLLY CLEO J (US) | 2004-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019210-A1 | Kinase inhibitors | CDK2, CDK1, CDK4 | FGFR4 191/4885FGFR1 88/4885FGFR2 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.