SCHEMBL4403435

SCHEMBL4403435

COc1ccc(C(=O)NCCC[N+](C)(C)C)cc1

nearest known ligand 0.74

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.74
RAB9A P51151 3/20 0.74
HPGD P15428 2/20 0.63
SMN1; SMN2 Q16637 2/20 0.63
ALDH1A1 P00352 4/20 0.57
KMT2A Q03164 1/20 0.56
SIGMAR1 Q99720 1/20 0.54
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
PKM P14618 1/20 0.54
POLB P06746 1/20 0.53
NFKB1 P19838 1/20 0.53
NFKB2 Q00653 1/20 0.53
RELA Q04206 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
NAMPT P43490 1/20 0.53
MAPT P10636 1/20 0.53
TSHR P16473 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13569383 0.87 NPC1 (0.68) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL11754310 0.85 NPC1 (1.00) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL11759659 0.85 NPC1 (1.00) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL11760286 0.85 NPC1 (1.00) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL11761105 0.85 NPC1 (1.00) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL9489987 0.85 NPC1 (1.00) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL11755990 0.85 NPC1 (1.00) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL11758269 0.85 NPC1 (1.00) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL11756315 0.85 NPC1 (1.00) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL16685001 0.84 NPC1 (0.83) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8367293-B2 Method for producing carrier for electrophotographic developer, carrier for electrophotographic developer, electrophotographic developer, and image forming method RICOH COMPANY, LTD. (JP) 2013-02-05 US disclosed
US-8329374-B2 Carrier, production method thereof, developer and image forming method RICOH COMPANY, LTD. (JP) 2012-12-11 US disclosed
US-8178273-B2 High density, durability; charging characteristics; dissolving coating in solution of supercritical and subcritical fluids; depositing on substrate by controlling pressure and/or temperature to reduce solubility RICOH COMPANY, LTD. (JP) 2012-05-15 US disclosed
US-8084181-B2 Oxidizing a pyrrole, pyrrole derivitive, or an aniline in a supercritical fluid forming an electrically conductive polymer; high image density without toner scattering and background smears RICOH COMPANY, LTD. (JP) 2011-12-27 US disclosed
US-8043785-B2 Coating material in carbon dioxide in liquid state, and forming coating layer on core material surface by reducing the solubility of the liquid RICOH COMPANY, LTD. (JP) 2011-10-25 US disclosed
US-20100310982-A1 METHOD FOR PRODUCING CARRIER FOR ELECTROPHOTOGRAPHIC DEVELOPER, CARRIER FOR ELECTROPHOTOGRAPHIC DEVELOPER, ELECTROPHOTOGRAPHIC DEVELOPER, AND IMAGE FORMING METHOD RICOH COMPANY, LTD. (JP) 2010-12-09 US disclosed
US-20090186292-A1 CARRIER, PRODUCTION METHOD THEREOF, DEVELOPER AND IMAGE FORMING METHOD RICOH COMPANY, LTD. (JP) 2009-07-23 US disclosed
US-20080280224-A1 CARRIER AND METHOD FOR PRODUCING THE SAME, DEVELOPER AND IMAGE FORMING METHOD RICOH COMPANY, LTD. (JP) 2008-11-13 US disclosed
US-20080138734-A1 CARRIER, METHOD FOR PRODUCING THE SAME, DEVELOPER, AND IMAGE FORMING METHOD RICOH COMPANY, LTD. (JP) 2008-06-12 US disclosed
US-20080063972-A1 CARRIER AND MANUFACTURING METHOD THEREOF, DEVELOPER, PROCESS CARTRIDGE, IMAGE FORMING APPARATUS, AND IMAGE FORMING METHOD RICOH COMPANY, LTD. (JP) 2008-03-13 US disclosed
US-20070202427-A1 TONER, METHOD FOR PREPARING THE TONER, DEVELOPER INCLUDING THE TONER, AND IMAGE FORMING METHOD AND APPARATUS AND PROCESS CARTRIDGE USING THE TONER RICOH COMPANY, LTD. (JP) 2007-08-30 US disclosed