⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4920447 | 1.00 | — | — | |
| SCHEMBL5521450 | 1.00 | — | — | |
| SCHEMBL8115501 | 1.00 | — | — | |
| SCHEMBL30287516 | 1.00 | — | — | |
| SCHEMBL438545 | 1.00 | — | — | |
| SCHEMBL1375335 | 1.00 | — | — | |
| SCHEMBL265423 | 1.00 | — | — | |
| SCHEMBL1688785 | 1.00 | — | — | |
| SCHEMBL10441953 | 0.97 | GABRR1 (0.48) | — | |
| SCHEMBL15770813 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117567266-B | Method for preparing 2-methylcyclopropyl carboxylic acid | 康龙化成手性医药技术(宁波)有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-117567266-A | Method for preparing 2-methylcyclopropyl carboxylic acid | 康龙化成手性医药技术(宁波)有限公司 | 2024-02-20 | — | — | CN | disclosed |
| US-20150216861-A1 | CYCLOPROPYL AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-08-06 | — | — | US | disclosed |
| US-9029381-B2 | Cyclopropyl amide derivatives | ASTRAZENECA AB (SE) | 2015-05-12 | — | — | US | disclosed |
| US-8981049-B2 | Aziridine mediated native chemical ligation | WASHINGTON STATE UNIVERSITY (US) | 2015-03-17 | — | — | US | disclosed |
| US-8486950-B2 | Janus kinase inhibitor compounds and methods | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-20130131311-A1 | AZIRIDINE MEDIATED NATIVE CHEMICAL LIGATION | WASHINGTON STATE UNIVERSITY (US) | 2013-05-23 | — | — | US | disclosed |
| US-20120065193-A1 | Cyclopropyl Amide Derivatives '978 | ASTRAZENECA AB (SE) | 2012-03-15 | — | — | US | disclosed |
| WO-2009005676-A2 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2009-01-08 | — | — | WO | disclosed |
| WO-2006043145-A1 | INHIBITORS OF HEPATITIS C VIRUS PROTEASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | PFIZER INC. (US) | 2006-04-27 | — | — | WO | disclosed |