Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.48 |
| ▸ | JAK2 | O60674 | 7/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.42 |
| ▸ | JAK1 | P23458 | 4/20 | 0.42 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2696072 | 0.89 | JAK3 (0.49) | JAK3JAK2IRAK4JAK1TYK2 | |
| SCHEMBL2695787 | 0.88 | JAK3 (0.50) | JAK3JAK2IRAK4JAK1TYK2 | |
| SCHEMBL2695187 | 0.86 | JAK3 (0.65) | JAK3JAK2IRAK4JAK1TYK2 | |
| SCHEMBL4406800 | 0.85 | JAK3 (0.51) | JAK3JAK2IRAK4JAK1TYK2 | |
| SCHEMBL2695243 | 0.85 | JAK3 (0.49) | JAK3JAK2IRAK4JAK1TYK2 | |
| SCHEMBL17326809 | 0.84 | JAK2 (0.45) | JAK3JAK2IRAK4JAK1TYK2 | |
| SCHEMBL2693721 | 0.82 | JAK3 (0.55) | JAK3JAK2IRAK4JAK1TYK2 | |
| SCHEMBL4404155 | 0.81 | JAK3 (0.55) | JAK3JAK2IRAK4JAK1TYK2 | |
| SCHEMBL2695354 | 0.80 | JAK3 (0.48) | JAK3JAK2IRAK4JAK1TYK2 | |
| SCHEMBL2695523 | 0.80 | JAK3 (0.53) | JAK3JAK2IRAK4JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9102625-B2 | Nicotinamides as JAK kinase modulators | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-08-11 | — | — | US | disclosed |
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | JAK3 4/4885JAK2 1/4885IRAK4 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.