Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 15/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 13/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8269112 | 1.00 | DPP4 (0.38) | DPP4DPP8DPP9CYP3A4MAPK8 | |
| SCHEMBL2705642 | 0.91 | DPP4 (0.41) | DPP4DPP8DPP9CYP3A4KCNH2 | |
| SCHEMBL2705653 | 0.91 | DPP4 (0.41) | DPP4DPP8DPP9CYP3A4KCNH2 | |
| SCHEMBL2701673 | 0.87 | DPP4 (0.50) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL2701676 | 0.87 | DPP4 (0.50) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL2704200 | 0.84 | DPP4 (0.44) | DPP4DPP8DPP9CYP3A4KCNH2 | |
| SCHEMBL2705645 | 0.81 | DPP4 (0.38) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL2705289 | 0.80 | DPP4 (0.53) | DPP4DPP8DPP9CYP3A4KCNH2 | |
| SCHEMBL4405019 | 0.79 | DPP4 (0.54) | DPP4DPP8DPP9CYP3A4KCNH2 | |
| SCHEMBL2703712 | 0.77 | DPP4 (0.46) | DPP4DPP8DPP9CYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888589-B1 | PYRROLOPYRIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | BRISTOL MYERS SQUIBB CO (US) | 2012-05-09 | — | — | EP | disclosed |