Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.51 |
| ▸ | AKT2 | P31751 | 20/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2277792 | 0.91 | AKT1 (0.54) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2271134 | 0.88 | AKT1 (0.55) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2271586 | 0.87 | AKT1 (0.55) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2273333 | 0.84 | AKT1 (0.52) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2271386 | 0.84 | AKT1 (0.63) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2277784 | 0.82 | AKT1 (0.68) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL3893437 | 0.81 | AKT1 (0.63) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2275346 | 0.81 | AKT1 (0.69) | AKT1AKT2KCNH2 | |
| SCHEMBL2276582 | 0.81 | AKT1 (0.66) | AKT1AKT2AKT3 | |
| SCHEMBL2279969 | 0.80 | AKT1 (0.53) | AKT1AKT2KCNH2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737843-A4 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2009-01-28 | — | — | EP | disclosed |
| EP-1737843-A1 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005100344-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2005-10-27 | — | — | WO | disclosed |