Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2406165 | 0.84 | HDAC1 (0.55) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL2406167 | 0.84 | HDAC1 (0.55) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL2406672 | 0.70 | HDAC1 (0.55) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL2406671 | 0.70 | HDAC1 (0.55) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL209692 | 0.69 | HDAC1 (0.60) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL209691 | 0.69 | HDAC1 (0.60) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL209897 | 0.69 | HDAC1 (0.60) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL2408945 | 0.69 | CASR (0.54) | HDAC1HDAC8HDAC6NOS2USP2 | |
| SCHEMBL210231 | 0.68 | HDAC1 (0.53) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL210919 | 0.68 | HDAC1 (0.53) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134680-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2009-12-23 | — | — | EP | claimed |
| WO-2008109994-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-09-18 | — | — | WO | claimed |
| EP-2134680-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008109994-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-09-18 | — | — | WO | disclosed |