⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4408920 | 1.00 | — | — | |
| SCHEMBL7185807 | 0.80 | TP53 (0.40) | — | |
| SCHEMBL7185803 | 0.80 | TP53 (0.40) | — | |
| SCHEMBL2858074 | 0.80 | TP53 (0.40) | — | |
| SCHEMBL28767303 | 0.74 | TP53 (0.35) | — | |
| SCHEMBL8548242 | 0.74 | — | — | |
| SCHEMBL21844017 | 0.74 | SMN1; SMN2 (0.37) | — | |
| SCHEMBL29625187 | 0.74 | SLC7A5 (0.36) | — | |
| SCHEMBL13529015 | 0.72 | — | — | |
| SCHEMBL24996113 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560482-B2 | Inhibitors of plasmepsins | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-07-14 | — | — | US | claimed |
| US-20050037953-A1 | Inhibitors of plasmepsins | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-02-17 | — | — | US | claimed |
| WO-2002074719-A2 | INHIBITORS OF PLASMEPSINS | THE JOHNS HOPKINS UNIVERSITY (US) | 2002-09-26 | — | — | WO | claimed |
| EP-0490667-B1 | HIV protease inhibitors | JAPAN ENERGY CORP (JP) | 1999-06-09 | — | — | EP | claimed |
| US-7560482-B2 | Inhibitors of plasmepsins | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-07-14 | — | — | US | disclosed |
| US-20050037953-A1 | Inhibitors of plasmepsins | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-02-17 | — | — | US | disclosed |
| WO-2002074719-A2 | INHIBITORS OF PLASMEPSINS | THE JOHNS HOPKINS UNIVERSITY (US) | 2002-09-26 | — | — | WO | disclosed |
| US-6291432-B1 | (R)-N-(2-METHYLBENZYL)-3-((2S, 3S)-3-(N-(2-CHROMONECARBONYL)-L-ASPARAGINYL)AMINO-2-HYDROXY-4-PHENYLBUTANO YL)-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE CAN BE GIVEN AS A TYPICAL EXAMPLE OF THIS COMPOUND. | JAPAN ENERGY CORPORATION (JP) | 2001-09-18 | — | — | US | disclosed |
| EP-0490667-B1 | HIV protease inhibitors | JAPAN ENERGY CORP (JP) | 1999-06-09 | — | — | EP | disclosed |
| EP-0900566-A1 | NOVEL TRIPEPTIDE COMPOUNDS AND ANTI-AIDS DRUGS | JAPAN ENERGY CORPORATION (JP) | 1999-03-10 | — | — | EP | disclosed |
| EP-0574135-B1 | Process for producing peptide derivatives and salts thereof | JAPAN ENERGY CORP (JP) | 1998-11-18 | — | — | EP | disclosed |
| US-5644028-A | Process for producing peptide derivatives and salts therefor | JAPAN ENERGY CORPORATION (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0574135-A1 | Process for producing peptide derivatives and salts thereof | JAPAN ENERGY CORPORATION (JP) | 1993-12-15 | — | — | EP | disclosed |