Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.82 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.82 |
| ▸ | MTOR | P42345 | 15/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3592142 | 1.00 | PIK3CA (0.82) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3604925 | 0.94 | PIK3CA (0.87) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3593050 | 0.92 | PIK3CA (0.72) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3588158 | 0.90 | PIK3CA (1.00) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3600793 | 0.90 | PIK3CA (0.83) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3596728 | 0.90 | PIK3CA (0.69) | PIK3CAPIK3CDMTOR | |
| SCHEMBL13948511 | 0.90 | PIK3CA (0.86) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3606436 | 0.88 | PIK3CA (0.67) | PIK3CAPIK3CDMTOR | |
| SCHEMBL4407972 | 0.88 | PIK3CA (0.81) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3594241 | 0.88 | PIK3CA (0.81) | PIK3CAPIK3CDMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |