⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2521993 | 0.77 | — | — | |
| SCHEMBL16629527 | 0.76 | — | — | |
| SCHEMBL10953037 | 0.76 | — | — | |
| SCHEMBL15401757 | 0.76 | — | — | |
| SCHEMBL19805376 | 0.74 | HDAC8 (0.31) | — | |
| SCHEMBL10933572 | 0.72 | KDM4E (0.45) | — | |
| SCHEMBL24013539 | 0.72 | KDM4E (0.34) | — | |
| SCHEMBL21720948 | 0.72 | GAA (0.40) | — | |
| SCHEMBL352659 | 0.72 | KDM4E (0.46) | — | |
| SCHEMBL18436350 | 0.72 | AR (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113278027-B | Preparation method of antitumor drug Laolatinib | 浙江合聚生物医药有限公司 | 2022-05-31 | — | — | CN | claimed |
| CN-113278027-A | Preparation method of antitumor drug Laolatinib | 浙江合聚生物医药有限公司 | 2021-08-20 | — | — | CN | claimed |
| CN-109081810-A | The synthetic method of 1- methyl-3-((methylamino) methyl)-1H- pyrazoles-5- nitrile | 沈阳药科大学 | 2018-12-25 | — | — | CN | claimed |
| US-20240101531-A1 | PYRIDINAMINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | XENON PHARMACEUTICALS INC. (CA) | 2024-03-28 | — | — | US | disclosed |
| WO-2022259210-A1 | NOVEL PROCESS FOR PREPARATION OF 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-5-OL | INCOR RENOVIS PHARMA PRIVATE LIMITED (IN) | 2022-12-15 | — | — | WO | disclosed |
| US-11517561-B2 | Macrocycle and composition comprising thereof | SHENZHEN TARGETRX, INC. (CN) | 2022-12-06 | — | — | US | disclosed |
| CN-113278027-B | Preparation method of antitumor drug Laolatinib | 浙江合聚生物医药有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-113278027-B | Preparation method of antitumor drug Laolatinib | 浙江合聚生物医药有限公司 | 2022-05-31 | — | — | CN | disclosed |
| US-20220144854-A1 | MACROCYCLIC COMPOUNDS | ZENO MANAGEMENT, INC. | 2022-05-12 | — | — | US | disclosed |
| US-20220144854-A1 | MACROCYCLIC COMPOUNDS | ZENO MANAGEMENT, INC. | 2022-05-12 | — | — | US | disclosed |
| CN-113950481-A | Macrocyclic compounds | 芝诺管理公司 | 2022-01-18 | — | — | CN | disclosed |
| EP-1585743-B1 | 2-(1H-INDAZOL-6-YLAMINO)- BENZAMIDE COMPOUNDS AS PROTEIN KINASES INHIBITORS USEFUL FOR THE TREATMENT OF OPHTHALMIC DISEASES | PFIZER (US) | 2007-05-23 | — | — | EP | disclosed |
| US-20060160858-A1 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS INC. | 2006-07-20 | — | — | US | disclosed |
| US-7053107-B2 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| WO-2006043145-A1 | INHIBITORS OF HEPATITIS C VIRUS PROTEASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | PFIZER INC. (US) | 2006-04-27 | — | — | WO | disclosed |
| CN-1747950-A | 2- (1H-indazol-6-ylamino) -benzamide compounds as protein kinase inhibitors for the treatment of ocular diseases | PFIZER (US) | 2006-03-15 | — | — | CN | disclosed |
| EP-1585743-A1 | 2-(1H-INDAZOL-6-YLAMINO)- BENZAMIDE COMPOUNDS AS PROTEIN KINASES INHIBITORS USEFUL FOR THE TREATMENT OF OPHTHALMIC DISEASES | PFIZER INC. (US) | 2005-10-19 | — | — | EP | disclosed |
| US-20040192735-A1 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2004-09-30 | — | — | US | disclosed |
| WO-2004056806-A1 | 2-(1H-INDAZOL-6-YLAMINO)-BENZAMIDE COMPOUNDS AS PROTEIN KINASES INHIBITORS USEFUL FOR THE TREATMENT OF OPHTALMIC DISEASES | PFIZER INC. (US) | 2004-07-08 | — | — | WO | disclosed |
| EP-0095289-B1 | IMIDAZO(1,2-C)PYRAZOLO(3,4-E)PYRIMIDINES AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1986-12-30 | — | — | EP | disclosed |